Initially Juvederm was tested in two U.S based clinics which helped to evaluate Juveder Ultra also known as Juvederm Ultra Plus to check and ensure safety and effectiveness of these products. In both clinics about 145 subjects were followed for about 24 weeks after injecting Juvederm Injection in one nasolabial fold.

Juvederm results were similar to Zyplast dermal filler as they both were injected to opposite nasolabial folds and the duration and frequency was noted very similar. In the trial it was noted that about 80-90% patients complained about redness, pain, firmness, lumps and swelling and 60% felt bruising. Itching and discoloration was noted in 35% patients. Other types of cosmetic facial fillers also have these side-effects.

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Juvederm took the edge on Zyplast as patients who used Juvederm got improvement with success rate of 88-90% compared to 36-40% of Zyplast. After the study we 84-88% preferred Juvederm Ultra and Juvederm Voluma injectable gel and only 5-10% preferred Zyplast. 5-6% said that they will not like to use of these products again.

Out of 146 patients 111-116 patients returned for repeat treatment in an average of 36 weeks after their last treatment. 48 people returned for treatment after 36 weeks and about 81% patients told that they noticed maintained improvement with Juvederm Ultra injectable gel.

Patients were asked to rate the improvement from 0 to 4, 0 for no improvement and 4 for great improvement after 2 weeks. Most patients gave good feedback.

Safety Information

As a dermatologist you must not recommend Juvedern Injectable gel to patients who have allergenic problems or have a history of such problems. Juvederm should not be used for patients who have allergy with gram-positive bacterial proteins. People who have problem with lidocaine should also avoid using both Juvederm Ultra and Juvederm Voluma.


Please do not inject Juvederm injectable gel in blood vessels or veins, otherwise it can cause problems like Embolism . If the patient has any infections at the place of treatment, then the treatment must be stopped or the gel should be injected from some else area.

Please read more about Embolism at Realself where Dr. M. Christine Lee, MD has explained the reason of this problem and prevention techniques quite nicely.

You must only use Juvederm under supervision of a licensed and experienced practitioner who has specialty in this field.

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